Evidence has been presented that translocation could use several different pathways for uptake. In addition, the mechanism of translocation can be dependent on whether the peptide is free or attached to cargo. To solve this problem, contrast agents with disulfide, reversible bond between metal chelate and transduction moiety enhance the cell-associated retention. Studies of the chemistry of the luminal plasma membrane of rat bladder epithelial cells. Think about the value of 0. We can use an equation relating permeability to properties of the diffusing molecule to see how well permeability correlates with the dissolvability of molecules in nature.
Cell-penetrating peptide - Wikipedia
Lipid Solubility and Drug Penetration of the Blood Brain Barrier
Description: Aspirin, for example, has a V d of 0. It facilitates the formation of stable foldamers with distinct secondary structure. Of course, this generality disregards the effects of the other two factors lipid solubility, number of -OH groups. Applications of SPIO includes cell labeling in vivo ; due to low toxicity, they are clinically approved for use in liver, spleen, and gastrointestinal imaging.